Our Group studies mechanisms of invasion and angiogenesis under physiological and pathological conditions. The role of proteases in invasion and angiogenesis is the major focus of our work.
Human Placenta: We compare the set of proteases required for physiological invasion versus physiological angiogenesis from cells deriving from the same organ, and seek for the proteases specific for each process.
Tumours: In cancer cells elevated levels of proteases is necessary for tumour cell proteolysis of host barriers, such as the basement membrane, tumour cell migration, and tumour cell colony formation in the target organ for metastasis. Using the chick chorioallantoic membrane assay, we propose to study the role of proteases in the invasion and angiogenesis of tumour cells in an in vivo system.
Key words: NETs, tumour spheroid culture, ex ovo chicken chorioallantoic membrane assay, invasion, angiogenesis, metalloproteases