We investigate the significance of T-lymphocytes in inflammation and autoimmunity with a special emphasis on metabolic regulation of T cell reactions. We apply a multidisciplinary approach that comprises in vitro studies and in vivo disease models in order to identify new molecular and metabolic pathways that control the pathogenicity of T cells.
The research focus of the lab is on regulating immune responses in the context of autoimmune disease. Special attention is paid to explaining the role of environmental factors such as aging, nutrition and metabolism as well as their interaction in the regulation of autoreactive T cells.
Dendritic cells are present in many organs and tissues and are capable of activating naive T lymphocytes and thus inducing immune responses to microbial and cell antigens. They appear to drive immunity vs. tolerance and exist as multiple functionally relevant subsets. We investigate their development and function in immune homeostasis and disease processes.