We are studying the role of myelopoietic and dendritic cells in anti-microbial immunity, autoimmune-inflammatory diseases and cancer. Specific projects aim at deciphering the molecular mechanisms underlying leukocyte differentiation under normal and diseased conditions (signaling processes, transcription factors, nuclear hormone receptors, miRNAs). Emphasis is put on understanding the role of the micro-environment in leukocyte differentiation within normal epithelia and carcinomas. Additional projects aim to characterize microbial sensing mechanisms in dendritic cells at body surfaces. We employ primary cell-based human models of immune cell differentiation, primary cancer cell models, T cell assays, human in vivo analyses, gene transduction and validation of findings in murine models.